Osamu Yokoyama Selected Research

Lower Urinary Tract Symptoms

1/2018	Early improvement of storage or voiding symptoms by tadalafil predicts treatment outcomes in patients with lower urinary tract symptoms from benign prostatic hyperplasia.
1/2017	Safety and efficacy of the combination of once-daily tadalafil and alpha-1 blocker in Japanese men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: A randomized, placebo-controlled, cross-over study.
10/2015	Tadalafil for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a review of clinical data in Asian men and an update on the mechanism of action.
5/2015	Add-on anticholinergic therapy for residual nocturia in patients with lower urinary tract symptoms receiving α1-blocker treatment: a multi-centre, prospective, randomised study.
4/2015	Tadalafil 5 mg once daily for the treatment of Asian men with lower urinary tract symptoms secondary to benign prostatic hyperplasia: analyses of data pooled from three randomized, double-blind, placebo-controlled studies.
3/2015	Effects of the 5α-reductase inhibitor dutasteride on rat prostate α1A-adrenergic receptor and its mediated contractility.
7/2014	Tadalafil 5 mg once-daily therapy for men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: results from a randomized, double-blind, placebo-controlled trial carried out in Japan and Korea.
1/2014	Alpha 1-adrenoceptor blocker may improve not only voiding but also storage lower urinary tract symptoms caused by (125) I brachytherapy for prostate cancer.
2/2013	Tadalafil once daily for lower urinary tract symptoms suggestive of benign prostatic hyperplasia: a randomized placebo- and tamsulosin-controlled 12-week study in Asian men.
1/2013	IPSS is lower in hypertensive patients treated with angiotensin-II receptor blocker: posthoc analyses of a lower urinary tract symptoms population.

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Osamu Yokoyama Research Topics

Disease

29	Overactive Urinary Bladder (Overactive Bladder) 11/2021 - 04/2004
17	Cerebral Infarction 08/2017 - 01/2002
14	Neoplasms (Cancer) 04/2021 - 05/2004
13	Nocturia 11/2021 - 04/2010
13	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 01/2019 - 09/2006
12	Lower Urinary Tract Symptoms 01/2018 - 09/2008
11	Prostatic Neoplasms (Prostate Cancer) 01/2021 - 01/2011
10	Urinary Incontinence 11/2021 - 04/2014
6	Urinary Retention 09/2021 - 11/2007
6	Renal Cell Carcinoma (Grawitz Tumor) 01/2021 - 09/2011
6	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 08/2017 - 11/2002
5	Spinal Cord Injuries (Spinal Cord Injury) 09/2021 - 02/2004
5	Carcinoma (Carcinomatosis) 01/2021 - 01/2011
5	Inflammation (Inflammations) 10/2020 - 02/2010
5	Polyuria 05/2015 - 04/2011
4	Stress Urinary Incontinence 01/2021 - 11/2013
4	Neoplasm Metastasis (Metastasis) 01/2021 - 01/2013
3	Urinary Bladder Neck Obstruction (Bladder Neck Obstruction) 01/2019 - 11/2007
2	Hematuria 09/2021 - 05/2008
2	Hypertension (High Blood Pressure) 01/2018 - 11/2015
2	Constipation 01/2018 - 04/2014
2	Ataxia (Dyssynergia) 11/2016 - 02/2004
1	Hypoxia (Hypoxemia) 06/2022
1	Ischemia 06/2022
1	Pyelonephritis 12/2021
1	Hypoalbuminemia 12/2021
1	Diarrhea 12/2021
1	Hemorrhage 09/2021
1	Multiple Sclerosis 09/2021
1	Epididymitis 09/2021
1	Autonomic Dysreflexia 09/2021

Drug/Important Bio-Agent (IBA)

9	Muscarinic AntagonistsIBA 01/2019 - 11/2005
8	Cholinergic Antagonists (Anticholinergics)IBA 01/2021 - 10/2009
7	Tadalafil (Cialis)FDA Link 01/2020 - 02/2013
5	Hormones (Hormone)IBA 01/2021 - 05/2004
5	resiniferatoxinIBA 01/2019 - 11/2005
5	propiverineIBA 01/2018 - 04/2011
5	Solifenacin Succinate FDA Link 10/2015 - 07/2011
5	imidafenacinIBA 05/2015 - 06/2011
5	Tamsulosin (Flomax)FDA LinkGeneric 01/2014 - 04/2011
4	Docetaxel (Taxotere)FDA Link 10/2019 - 01/2011
4	naftopidilIBA 01/2019 - 01/2006
3	Type A Botulinum Toxins (Botox)FDA Link 11/2021 - 03/2020
3	Prostate-Specific Antigen (Semenogelase)IBA 11/2021 - 05/2013
3	Botulinum Toxins (Botulinum Toxin)IBA 09/2021 - 03/2020
3	Polysaccharides (Glycans)IBA 01/2021 - 11/2015
3	Sialyl Lewis X AntigenIBA 01/2021 - 11/2015
3	LigandsIBA 01/2021 - 10/2012
3	N- (4- ((5- (hydroxy(phenyl)methyl)pyrrolidin- 2- yl)methyl)phenyl)- 4- oxo- 4,6,7,8- tetrahydropyrrolo(1,2- a)pyrimidine- 6- carboxamideIBA 01/2021 - 01/2019
3	Phosphodiesterase 5 InhibitorsIBA 01/2020 - 10/2015
3	salicylhydroxamic acid (SHAM)IBA 01/2019 - 12/2007
3	mirabegronIBA 01/2019 - 06/2014
3	Therapeutic UsesIBA 01/2018 - 01/2011
3	Tolterodine Tartrate (Detrol)FDA Link 04/2014 - 11/2005
2	E-SelectinIBA 01/2021 - 11/2015
2	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/2021 - 05/2013
2	CA-19-9 Antigen (CA 19-9 Antigen)IBA 01/2021 - 11/2015
2	CarbohydratesIBA 01/2021 - 10/2017
2	C-Reactive ProteinIBA 10/2020 - 01/2019
2	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2020 - 09/2008
2	DNA (Deoxyribonucleic Acid)IBA 11/2019 - 06/2004
2	Dinoprostone (PGE2)FDA Link 01/2018 - 06/2011
2	fesoterodine FDA Link 01/2018 - 04/2014
2	Proteins (Proteins, Gene)FDA Link 10/2017 - 02/2010
2	Nerve Growth Factor (NGF)IBA 08/2017 - 11/2010
2	Halothane (Fluothane)FDA Link 08/2017 - 05/2003
2	Monoclonal AntibodiesIBA 11/2015 - 10/2012
2	oxybutynin (Tavor)FDA LinkGeneric 07/2015 - 04/2014
2	silodosin FDA Link 01/2014 - 09/2006
2	Adrenergic Receptors (Adrenergic Receptor)IBA 11/2013 - 10/2008
2	Prednisolone (Predate)FDA LinkGeneric 09/2013 - 05/2013
2	Paclitaxel (Taxol)FDA LinkGeneric 05/2013 - 03/2011
2	Carboplatin (JM8)FDA LinkGeneric 05/2013 - 03/2011
2	Cisplatin (Platino)FDA LinkGeneric 01/2013 - 03/2011
2	Sunitinib (Sutent)FDA Link 11/2011 - 09/2011
2	Pharmaceutical PreparationsIBA 06/2011 - 05/2003
2	Adenosine Triphosphate (ATP)IBA 06/2011 - 11/2002
2	Cyclooxygenase InhibitorsIBA 01/2011 - 02/2010
2	N-Methylaspartate (NMDA)IBA 01/2010 - 01/2002
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2010 - 01/2002
2	Glutamate Receptors (Glutamate Receptor)IBA 01/2010 - 04/2004
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2010 - 07/2005
2	Messenger RNA (mRNA)IBA 05/2003 - 01/2002
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 06/2022
1	8-Hydroxy-2'-DeoxyguanosineIBA 06/2022
1	CytokinesIBA 06/2022
1	Amyloid (Amyloid Fibrils)IBA 12/2021
1	AA amyloidosisIBA 12/2021

Therapy/Procedure

18	Therapeutics 03/2021 - 05/2004
6	Drug Therapy (Chemotherapy) 10/2019 - 03/2011
5	Castration 01/2021 - 05/2013
2	Conservative Treatment 10/2017 - 01/2010
2	Anesthesia 08/2017 - 05/2003
2	Lasers (Laser) 05/2017 - 06/2013
2	Brachytherapy 01/2016 - 01/2014
2	Orchiectomy (Orchidectomy) 04/2015 - 05/2003
2	Nephrectomy 11/2013 - 11/2011
2	Combination Drug Therapy (Combination Chemotherapy) 09/2013 - 03/2011
2	Prostatectomy (Retropubic Prostatectomy) 05/2013 - 05/2004
1	Injections 09/2021